Effect of sodium silicate concentration on the physico-chemical properties of dual-setting bone-like apatite cements

Calcium phosphate cements (CPCs) with their biocompatibility, osteoconductivity and injectability plays an important role in bone defects treatment. Dual-setting cement is a promising approach to improve the physicochemical biological properties of CPCs which liquid phase contains dissolved monomers that polymerized during hardening process. In this study, series dual-setting were prepared by mixing dicalcium dihydrate (DCPD) as solid sodium silicate solution (SS) different concentrations liquids. The idea was evaluate effect SS concentration on setting mechanism, mechanical formulated cements. kinetics attributed DCPD dissolution calcium deficient hydroxyapatite (CDHA) precipitation parallel polymerization form gel. This responsible for formation interpenetrating composite material formed gel fills micropores CPC cement. results showed time can be modulated varying concentrates liquid. It shown, content increased from 10 30 wt%, decreased 56 5 min. Moreover, CDHA accelerated increasing concentration. bone-like apatite highest exhibited enhanced compressive strength high resorption rates. Overall, addition regulate apatite-forming used fracture